BCMTexas Children's HospitalJan and Dan Duncan Neurological Research Institute
Department of Neurology   |   Department of Molecular and Human Genetics
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Our mission is to understand genetic mechanisms of Alzheimer's and Parkinson's disease, and to translate these insights to enhance risk prediction, diagnosis and treatment of these disorders. To achieve these goals, we integrate human genomic analyses with functional investigation in fruit fly models of neurodegenerative disease. Our innovative strategy is revealing genetic pathways of cognition and motor control, and their impact in the aging brain.

Joshua M. Shulman, MD, PhD
Principal Investigator and Associate Professor
Departments of Neurology, Molecular and Human Genetics, Neuroscience and Program in Developmental Biology
Baylor College of Medicine
Jan and Dan Duncan Neurological Research Institute
Texas Children's Hospital

News & Events

September 29, 2020
Our new study reveals an integrated transcriptome-proteome atlas of tauopathy, highlighting pervasive overlap with brain aging. Read the paper.

July 28, 2020
We explore the relative contribution of single nucleotide and copy number variants to Parkinson's disease risk. Read the paper.

July 14, 2020
Which mouse model is the best match for Alzheimer's disease gene expression signatures in the human brain? Read our new paper.

April 24, 2020
Our new study reveals retromer-mediated mechanisms in the aging brain relevant to Alzheimer's and Parkinson's disease. Read the paper.

March 20, 2020
Pinghan Zhao joins the lab as a graduate student in Neuroscience Welcome!

October 8, 2019
Tau disrupts the spliceosome and triggers splicing errors and neurodegeneration—our new study integrates analyses of human postmortem brain with experiments in flies to reveal new mechanisms of Alzheimer's disease. Read the paper.

August 13, 2019
In a new study combining experiments in Drosophila and mouse models as well as human postmortem brains, we implicate the Alzheimer's disease risk gene, CD2AP, in synaptic proteostasis and plasticity. Read the paper.

May 30, 2019
Matea Paveskovic (Neuroscience) and Tim Wu (Molecular & Human Genetics / MSTP) join the lab as graduate students. Welcome!

January 9, 2019
New manuscript preprint released from the lab describes novel mechanism for Tau-mediating neuronal injury in Alzheimer's disease, converging on RNA splicing.

January 3, 2019
New manuscript preprint released from the lab describes overlap between Alzheimer's disease brain gene expression signatures in humans and mouse models.

July 2, 2018
Emily Hill joins the lab as a clinical fellow. Welcome!

June 5, 2018
In a new study combining analyses in human postmortem brains and Drosophila models, the lab reports that Tau pathology activates transposable elements in Alzheimer's disease. Read the paper.

May 1, 2018
Grant Mangleburg joins the lab as a graduate student from the Baylor College of Medicine Molecular & Human Genetics and Medical Scientist Training Program. Welcome!

January 8, 2018
Sindhu Rao joins the lab as Research Coordinator. Welcome!

More News

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