BCMTexas Children's HospitalJan and Dan Duncan Neurological Research Institute
Department of Neurology   |   Department of Molecular and Human Genetics   |   Center for Alzheimer's and Neurodegenerative Diseases
Research      |      Our Team      |      Publications      |      For Patients      |      Contact Us
Welcome

Our mission is to understand genetic mechanisms of Alzheimer's and Parkinson's disease, and to translate these insights to enhance risk prediction, diagnosis and treatment of these disorders. To achieve these goals, we integrate human genomic analyses with functional investigation in fruit fly models of neurodegenerative disease. Our innovative strategy is revealing genetic pathways of cognition and motor control, and their impact in the aging brain.

Joshua M. Shulman, MD, PhD
Principal Investigator and Professor
Departments of Neurology, Molecular and Human Genetics, Neuroscience
Director, Center for Alzheimer's and Neurodegenerative Diseases
Baylor College of Medicine
Jan and Dan Duncan Neurological Research Institute
Texas Children's Hospital
Email:

News & Events

February 23, 2026
Dr. Joshua Shulman delivered the 24th Annual Frank M. Townsend, M.D. Lecture at UT Health San Antonio, titled "Resolving Alzheimer's Disease Heterogeneity Through Functional Genomics".

February 14, 2026
Pinghan Zhao and colleagues published a new study identifying excitotoxic mechanisms in Alzheimer's disease, and featuring our FlyNDA web tool. Read the paper | FlyNDA

February 5, 2026
Congratulations to Mingxue Gu and Ruth De-Paula for leading the effort to uncover the genetic and cellular mechanisms driving Parkinson's disease and neurodegeneration in their hot-off-the-press papers in Molecular Neurodegeneration and Brain. Read the papers

January 12, 2026
We congratulate Pinghan Zhao for successfully defending his thesis work "Systems genetic dissection of brain gene expression reveals excitotoxic mechanisms of Alzheimer's disease"

December 4, 2025
We congratulate Jennifer Deger and team for publishing "Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila" in Human Molecular Genetics. Read the paper

October 13, 2025
We congratulate Jennifer Deger for successfully defending her thesis work "Revealing the nervous system requirements of Alzheimer's disease risk genes in Drosophila".

October 13, 2025
We congratulate Jeffrey Kim for for receiving the Silverstein Foundation Postdoctoral Fellowship Award.

August 16, 2024
We show that CD2AP is vital for neuron structure and function, pointing to a potential role in AD. Read the paper

October 18, 2021
Welcome to our new clinical research coordinators, Fatima Chavez and Teah Segura, and new research technician, Michelle Etoundi!

April 1, 2021
We explore genetic modifiers of Parkinson's in a genome-wide association study for disease motor subtypes. Read the paper

March 1, 2021
Jennifer Deger joins the lab as a graduate student in Neuroscience and the Medical Scientist Training Program-Welcome!

February 10, 2021
Our new study uses biosensor-based quantitative motor phenotyping to resolve Parkinson's disease heterogeneity. Read the paper

September 29, 2020
Our new study reveals an integrated transcriptome-proteome atlas of tauopathy, highlighting pervasive overlap with brain aging. Read the paper.

July 28, 2020
We explore the relative contribution of single nucleotide and copy number variants to Parkinson's disease risk. Read the paper.

July 14, 2020
Which mouse model is the best match for Alzheimer's disease gene expression signatures in the human brain? Read our new paper.

April 24, 2020
Our new study reveals retromer-mediated mechanisms in the aging brain relevant to Alzheimer's and Parkinson's disease. Read the paper.

March 20, 2020
Pinghan Zhao joins the lab as a graduate student in Neuroscience Welcome!

October 8, 2019
Tau disrupts the spliceosome and triggers splicing errors and neurodegeneration—our new study integrates analyses of human postmortem brain with experiments in flies to reveal new mechanisms of Alzheimer's disease. Read the paper.

August 19, 2020
Baylor College of Medicine announces Dr. Shulman as founding director for the new Center for Alzheimer's and Neurodegenerative Diseases. Read the paper.

August 13, 2019
In a new study combining experiments in Drosophila and mouse models as well as human postmortem brains, we implicate the Alzheimer's disease risk gene, CD2AP, in synaptic proteostasis and plasticity. Read the paper.

May 30, 2019
Matea Paveskovic (Neuroscience) and Tim Wu (Molecular & Human Genetics / MSTP) join the lab as graduate students. Welcome!

January 9, 2019
New manuscript preprint released from the lab describes novel mechanism for Tau-mediating neuronal injury in Alzheimer's disease, converging on RNA splicing.

January 3, 2019
New manuscript preprint released from the lab describes overlap between Alzheimer's disease brain gene expression signatures in humans and mouse models.


More News



Resources

FlyNDA
Web-based resource for exploring neurodegeneration-associated gene expression modules in Drosophila. Open

ALICE
Cross-species portal to identify causal Alzheimer's risk-locus genes and their nervous system requirements in Drosophila. Open

Copyright © 2013–2026 The Laboratory for Integrative Functional Genomics. Original site by Academic Web Pages. Maintained and updated by Luke Parkitny, Laboratory for Integrative Functional Genomics. Banner photo credits: Mel Feany and Welcome Bender.