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Department of Neurology   |   Department of Molecular and Human Genetics
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Publications

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Papers

2017

Wangler M, Hu, Y, Shulman, JM. Drosophila and Genome-wide Association Studies: a Review and Resource for the Functional Dissection of Human Complex Traits. Disease Models & Mechanisms. 2017; 10:77-88. [PDF]

Chibnik, LC, White, CC, Mukherjee, S, Raj, T, Yu, L, Larson, EB, Montine, TJ, Keene, D, Sonnen, J, Schneider, JA, Crane, PK, Shulman, JM, Bennett, DA, De Jager PL. Uncovering the genetic architecture of neurofibrillary tangles: role of the PTPRD locus and limited pleiotropy with other neuropathologies. Mol Psychiatry. Epub ahead of print. doi: 10.1038/mp.2017.20 [PDF]

Blauwendraat C, Faghri, F, Geiger, JT, Nalls, MA . . . Robak, L, Shulman, JM, Rogaeva, E, Hardy, JA, Singleton, AB, Scholz, SW. NeuroChip, an updated version of the NeuroX genotyping platform, to rapidly screen for variants associated with neurological diseases. Neurobiol Aging. 2017; 57:247.e9e247.e13 [PDF]

Rousseaux, MWC, Shulman, JM, Jankovic, J. Progress toward an integrated understanding of Parkinson's disease. F1000. F1000Research 2017; 6(F1000 Faculty Rev):1121 [PDF]

Jansen, IE*, Ye, H*, Heetveld, S*, Lechler, M*, Michels, H, Seinstra, RI, Lubbe, SJ, Drouet, V, Lesage, S, Majounie, E, Gibbs, JR, Nalls, MA, Simon-Sanchez, J, Castillo, M, Rizzu, P, Blauwendraat, C, Chouhan, AK, Li, Y, Yogi, P, International Parkinson's Disease Genetics Consortium (IPGDC), Morris, H, Brice, A, Singleton, AB, David, DD, Nollen, EA, Jain, S, Shulman, JM*, Heutink, P*. Discovery and functional prioritization of Parkinson's Disease candidate genes from large-scale whole-exome sequencing. Genome Biology. 2017; 18:20. doi: 10.1186/s13059-017-1147-9 [PDF]

2016

Muller, SH, Girard, SL, Hopfner, F, Merner, ND, Bourassa, CV, Lorenz, D, Clark, LN, Tittmann, L, Soto-Ortolaza, AI, Klebe, S, Hallett, M, Schneider, SA, Hodgkinson, CA, Lieb, W, Wszolek, ZK, Pendziwiat, M, Lorenzo-Betancor, O, Poewe, W, Ortega-Cubero, S, Seppi, K, Rajput, A, Hussl, A, Rajput, AH, Berg, D, Dion, PA, Wurster, I, Shulman, JM, Srulijes, K, Haubenberger, D, Pastor, P, Vilariño-Güell, C, Postuma, RB, Bernard, G, Ladwig, KH, Dupré, N, Jankovic, J, Strauch, K, Panisset, M, Winkelmann, J, Testa, CM, Reischl, E, Zeuner, KE, Ross, OA, Arzberger, T, Chouinard, S, Deuschl, G, Louis, ED, Kuhlenbäumer, G, Rouleau, GA. Genome-wide Association Study in Essential Tremor identifies three new loci. Brain. Epub ahead of print. doi: 10.1093/brain/aww242 [PDF]

Jakobsdottir, J, van der Lee, SJ, Bis, JC, Chouraki, V, Li-Kroeger, D, Yamamoto, S, Grove, ML, Naj, A, Vronskaya, M, Salazar, JL, DeStefano, AL, Brody, JA, Smith, AV, Amin, N, Sims, R, Ibrahim-Verbaas, CA, Choi, S-H, Satizabal, CL, Lopez, OL, Beiser, A, Ikram, MA, Garcia, ME, Hayward, C, Varga, TV, Ripatti, S, Franks, PW, Hallmans, G, Rolandsson, O, Jansson, J-H, Porteous, DJ, Salomaa, V, Eirkisdottir, G, Rice, KM, Bellen, HJ, Levy, D, Uitterlinden, AG, Emilsson, V, Rotter, JI, Aspelund, T, Cohorts for Heart and Aging Research in Genomic Epidemiology, Alzheimer's Disease Genetic Consortium, Genetic and Environmental Risk in Alzheimer's Disease, O'Donnell, CJ, Fitzpatrick, AL, Launer, LJ, Hofman, A, Wang, L-S, Williams, J, Schellenberg, GD, Boerwinkle, E, Psaty, BM, Seshadri, S, Shulman, JM*, Gudnason, V*, van Duijn, CM*. Rare loss-of-function variant in TM2D3 is associated with risk and onset of late-onset Alzheimer's disease. In revision. PLoS Genetics. 2016; 12(10):e1006327. doi: 10.1371/journal.pgen.1006327. [PDF]

Hales, CW, Dammer, EB, Deng, Q, Duong, DM, Gearing, M, Troncoso, JC, Thambisetty, M, Lah, JJ, Shulman, JM, Levey, AI, Seyfried, NT. Early changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease. Proteomics. Epub ahead of print. doi: 10.1002/pmic.201600057. [PDF]

Giri, A, Mok, KY, Jansen, I, Sharma, M, Tesson, C, Mangone, G, Lesage, S, Bras, JM, Shulman, JM, Sheering, U-M, International Parkinson's Disease Genetics Consortium (IPGDC), Diez-Fairen, M, Pastor, P, Marti, MJ, Ezquerra, M, Tolosa, E, Correia-Guedes, L, Ferreira, J, Amin, N, van Duijn, CM, van Rooij, J, Uitterlinden, AG, Kraaij, R, Nalls, M, Simon-Sanchez, J. Lack of evidence for a role of genetic variation in TMEM230 in the risk for Parkinson's disease in the Caucasian population. Neurobiology of Aging. Epub ahead of print. http://dx.doi.org/10.1016/j.neurobiolaging.2016.10.004 [PDF]

Chouhan, AK, Guo, C, Hsieh, Y-C, Senturk, M, Zuo, Zhongyuan, Li, Y, Chatterjee, S, Botas, J, Jackson, GR, Bellen, HJ, and Shulman, JM. Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease. Acta Neuropathologica Communications. 2016 4(1):62. doi: 10.1186/s40478-016-0333-4 [PDF]

Valenca, GT, Srivastava, GP, Oliveira-Filho, J, White, CC, Yu, L, Schneider, JA, Buchman, AS, Shulman, JM, Bennett, DA, De Jager, PD. The Role of MAPT Haplotype H2 and Isoform 1N/4R in Parkinsonism of Older Adults. PLoS One. 2016; 11(7):e0157452. doi: 10.1371/journal.pone.0157452 [PDF]

Ali, YO, Allen, HM, Yu, L, Li-Kroeger, D, Bakhshizadehmahmoudi, D, Hatcher, A, McCabe, C, Xu, J, Bjorklund, N, Taglialatela, G, Bennett, DA, De Jager, PL, Shulman, JM, Bellen, H, Lu, H-C. NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies. PLoS Biology. 2016; 14(6): e1002472. doi:10.1371/journal.pbio.1002472 [PDF]

2015

Farlow, JL, Robak, LA, Hetrick, K, Bowling, K, Boerwinkle, E, Akdemir, ZC, Gambin, T, Gibbs, RA, Gu, S, Jain, P, Jankovic, J, Jhangiani, SN, Kaw, K, Lin, H, Ling, H, Liu, Y, Lupski, JR, Muzny, D, Porter, P, Pugh, E, White, J, Doheny, K, Myers, RM, Shulman, JM*, Foroud, T*. Whole exome sequencing identifies candidate genes for Parkinson’s disease. JAMA Neurology. Epub ahead of print, doi:  10.1001/jamaneurol.2015.3266 [PDF] Editorial by Toft and Ross

Shulman, JM. Drosophila and experimental neurology in the post-genomic era. Experimental Neurology. 2015; Epub ahead of print, doi:  10.1016/j.expneurol.2015.03.016 [PDF]

Debette, S, Ibrahim-Verbaas, CA, Bressler, J, Schuur, M, Smith, A, Bis, JC, Davies, G, Wolf, C, Gudnason, V, Chibnik, LB, Yang, Q, deStefano, A, de Quervain, DJF, Srikanth, V, Lahti, J, Grabe, HJ, Smith, JA, Priebe, L, Yu, L, Karbalai, N, Hayward, C, Wilson, JF, Becker, J, Stegle, O, Mather, KA, Chouraki, V, Sun, Q, Rose, LM, Resnick, S, Oldmeadow, C, Kirin, M, Wright, AF, Jonsdottir, MK, Au, R, Becker, A, Amin, N, Nalls, MA, Turner, ST, Kardia, SLR, Oostra, B, Windham, G, Coker, LH, Zhao, W, Knopman, DS, Heiss, G, Griswold, ME, Gottesman, RF, Vitart, V, Hastie, ND, Zgaga, L, Rudan, I, Polasek, O, Holliday, EG, Schofield, P, Hoan Choi, S, Tanaka, T, An, Y, Perry, RT, Kennedy, RE, Sale, MM, Wang, J, Wadley, VG, Liewald, DC, Ridker, PM, Gow, AJ, Pattie, A, Starr, JM, Porteous, D, Liu, X, Thomson, R, Armstrong, NJ, Eiriksdottir, G, Assareh, AA, Kochan, NA, Widen, E, Palotie, A, Hsieh, Y-C, Eriksson, JG, Vogler, C, van Swieten, JC, Shulman, JM,  Beiser, A, Rotter, J, Schmidt, CO, Hoffman, W, Nothen, MM, Ferrucci, L, Attia, J, Uitterlinden, AG, Amouyel, P, Dartigues, J-F, Amieva, H, Raikkonen, K, Garcia, M, Wolf, PA, Hofman, A, Longstreth, WT, Psaty, BM, Boerwinkle, E, De Jager, PL, Sachdev, PS, Schmidt, R, Breteler, MMB, Teurner, A, Lopez, OL, Cichon, S, Chasman, DI, Grodstein, F, Muller-Myhsok, B, Tzourio, C, Papassotiropoulos, A, Bennett, DA, Ikram, MA, Deary, IJ, van Duijn, CM, Launer, L, Fitzpatrick, AL, Seshadri, S, and Mosley, TH for the CHARGE Consortium. Genome-wide studies of verbal declarative memory in non-demented older people: the cohorts for heart and aging research in genomic epidemiology consortium. Biol Psychiatry. 2015; 77:749-763. [PDF]

Ibrahim-Verbaas, CA, Bressler, J, Debette, S, Schuur, M, Smith, AV, Bis, JC, Davies, G, Trompet, S, Smith, JA, Wolf, C, Chibnik, LB, liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffman, P, Karjalainen, J, Lahti, J, Llewellyn, DJ, Schmidt, CO, Mather, KA, Mather, KA, Chouraki, V, Sun, Q, Resnick, SM, Rose, LM, Oldmeadow, C, Stewar, M, Smith, BH, Gudnason, V, Yang, Q, Mirza, SS, Jukema, JW, De Jager, PL, Harris, TB, Liewald, DC, Amin, N, Coker, LH, Stegle, O, Lopez, OL, Schmidt, R, Teumer, A, Ford, I, Karbalai, N, Becker, JT, Jonsdottir, MK, Au, R, Fehrmann, RSN, Herms, S, Nalls, M, Zhao, W, Turner, ST, Yaffe, K, Lohman, K, van Swieten, JC, Kardia, SLR, Knopman, DS, Meeks, WM, Heiss, G, Holliday, EG, Schofield, PW, Tanaka, T, Stott, DJ, Wang, J, Ridker, P, Gow, AJ, Pattie, A, Starr, JM, Hocking, LJ, Armstrong, NJ, McLachlan, S, Shulman, JM, Pilling, LC, Eiriksdottir, G, Scott, RJ, Kochan, NA, Palotie, A, Hsieh, Y-C, Eriksson, JG, Penman, A, Gottesman, RF, Oostra, BA, Yu, L, DeStefano, AL, Beiser, A, Garcia, M, Rotter, JI, Nothen, MM, Hofman, A, Slagboom, PE, Westendorp, RGJ, Buckley, BM, Wolf, PA, Uitterlinden, AG, Psaty, BM, Grabe, HJ, Bandinelli, S, Chasman, DI, Grodstein, F, Raikkonen, Lambert, J-C, Porteous, Generation Scotland, Price, JF, Sachdev, PS, Ferrucci, Attia, JR, Rudan, I, Hayward, C, Wright, AF, Wilson, JF, Cichon, S, Franke, L, Schmidt, H, Ding, J, de Craen, AJM, Fornage, M, Bennett, DA, Deary, IJ, Ikram, MA, Launer, LJ, Fitzpatrick, AL, Seshadri, S, van Duijn, CM, and Mosley, TH. GWAS for executive function and processing speed suggests involvement of the CADM2 gene. Mol Psychiatry 2015; Epub ahead of print, doi: 10.1038/mp.2015.37 [PDF]

2014

Buchman, AS, Yu, L, Wilson, RS, Shulman, JM, Boyle, PA, Bennett, DA. Harm avoidance is associated with the rate of progressive parkinsonism in community-dwelling older persons: a prospective cohort study. BMC Geriatrics. 2014; 14:54. [PDF]

Haelterman, NA, Yoon, WH, Sandoval, H, Jaiswal, M, Shulman, JM, Bellen, HJ. A mitocentric view of Parkinson’s Disease. Annual Review of Neuroscience. 2014; Epub ahead of print. [PDF]

Buchman, AS, Yu, L, Wilson, RS, Shulman, JM, Boyle, PA, Bennett, DA. Harm avoidance is associated with the rate of progressive parkinsonism in community-dwelling older persons: a prospective cohort study. BMC Geriatrics. 2014; 14:54. [PDF]

Shulman, JM, Yu, L, Buchman, AS, Evans, DA, Schneider, JA, Bennett, DA, De Jager, PL. Association of Parkinson Disease susceptibility loci with mild parkinsonian signs in older persons. JAMA Neurology. 2014; 71:429-35. [PDF] [Supplement]

Shulman, JM, Imboywa, S, Giagtzoglou, N, Powers, MP, Hu, Yanhui, Devenport, D, Chipendo, P, Chibnik, LB, Diamond A, Perrimon, N, Brown, NH, De Jager PL, Feany, MB. Functional screening in Drosophila identifies Alzheimer’s disease susceptibility genes and implicates Tau-mediated mechanisms. Human Molecular Genetics. 2014; 23:870-877 [PDF] [Supplement-1] [Supplement-2]

Sherva, R, Tripodis, Y, Bennett, D, Chibnik, LB, Crane, PK, De Jager, P, Farrer, LA, Saykin, AJ, Shulman, JM, Green, RC, ADNI. Genomewide Association Study of the Rate of Cognitive Decline in Alzheimer's Disease. Alzheimer's & Dementia. 2014; 10:45-52. [PDF]

2013

brainShulman JM. Structural variation and the expanding genomic architecture of Parkinsonís disease. JAMA Neurology. 2013; 70:1355-1356. [PDF]

Chou, SH*, Shulman, JM*, Keenan, B, Secor, EA Buchman, AS, Schneider, JA, Bennett, DA, De Jager, PL. Genetic susceptibility for ischemic infarction and arteriosclerosis based on neuropathologic evaluations. Cerebrovascular Diseases. 2013; 36:181-8. [PDF]
*Equal contribution.

Shulman, JM, Chen, K, Keenan, BT, Chibnik, LB, Thiyyagura, P, Liu, X, Roontive, A, Yu, L, McCabe, C, Patsopoulos, NA, Corneveaux, JJ, Huentelman, MJ, ADNI, Evans, DA, Schneider, JA, Reimain, EM, De Jager, PL, Bennett, DA. Genetic susceptibility for Alzheimer's disease neuritic plaque pathology. JAMA Neurology. 2013; 70:1150-7. [PDF]

Cruchaga, C, Kauwe, JSK, Harari, O, Jin, SC, Shulman, JM, De Jager, PL, Chibnik, LB, Bennett, DA, Arnold, SE, Van Deerlin, V, Lee, VM, Shaw, L, Trojanowski, J, Haines, JL, Mayeux, R, Pericak-Vance, MA, Farrer, LA, Schellenberg, GD, Peskind, ER, Galasko, D, Mayo, K, Bertelsen, S, Bailey, M, McKean, D, Fagan, AM, Holtzman, DM, Morris, JC, Alzheimerís Disease Genetic Consortium, Alzheimerís Disease Neuroimaging Initiative, GERAD Consortium, Goate, AM. A genome-wide association study for cerebrospinal fluid tau and phospho-tau levels identifies new candidate variants implicated in risk for Alzheimer's Disease. Neuron. 2013; 78:256-268. [PDF]

2012research image

Biffi, A, Shulman, JM, Jagiella, JM, Cortellini, L, Ayres, A, Schwab, K, Brown, DL, Silliman, SL, Selim, M, Worrall, BB, Meschia, JF, Slowik, A, De Jager, PL, Greenberg, SM, Schneider, JA, Bennett, DA, Rosand, J. Genetic Variation at CR1 Increases Risk and Severity of Cerebral Amyloid Angiopathy. Neurology. 2012; 78:334-341. [PDF]

Buchman, AS, Shulman, JM, Nag, S, Leurgans, SE, Schneider, JA, and Bennett, DA. Nigral Pathology and Parkinsonian Signs in Elders without Parkinson's Disease. Annals of Neurology. 2012; 71:258-266. [PDF]

De Jager, PL*, Shulman, JM*, Chibnik, LB*, Keenan, BT, Raj, T, Wilson, RS, Yu, L, Leurgans, SE, Tran, D, Aubin, C, Corneveaux, JJ, Huentelman, MJ, ADNI, Myers, AJ, Hardy, JA, Reiman, EM, Bennett, DA, and Evans, DA. A genome-wide scan for common variants affecting rate of age-related cognitive decline. Neurobiology of Aging. 2012; 33: 1017.e1-1017.e15. *Equal contribution. [PDF]

Yu, L, Shulman, JM, Chibnik, L, Leurgans, S, Schneider, JA, De Jager, PL, Bennett, DA.  The CETP I405V polymorphism is associated with increased risk of Alzheimer’s disease. Aging Cell. 2012; 11:228-233. [PDF]

Raj, T, Shulman, JM, Keenan, BT, Chibnik, LB, Evans, DA, Bennett, DA, Stranger, BE, and De Jager, PL. Alzheimer’s disease susceptibility: evidence for a protein network under natural selection. American Journal of Human Genetics. 2012; 90:720-726. [PDF]

Keenan, BT, Shulman, JM, Chibnik, LB, Raj, T, Tran, D, Sabuncu, MR, ADNI, Allen, A, Myers, AJ, Hardy, JA, Huentelman, MJ, Reiman, EM, Evans, DA, Bennett, DA, De Jager, PL. Functional fine-mapping of the CR1 locus identifies a causal variant. Human Molecular Genetics. 2012; 21:2377-2388. [PDF]

Bis*, JC, DeCarli*, C, Smith*, AV, van der Lijn*, F, Crivello*, F, Fornage*, M, Debette*, S, Shulman, JM et al. Genome-wide association studies implicate loci on Chromosome 12 in hippocampal volume. Nature Genetics. 2012; 44:545-551. *Equal contribution. [PDF]

Valant V, Keenan, BT, Anderson, CD, Shulman, JM, Devan, WJ, Ayres, AM, Schwab, K, Goldstein, JN, Viswanathan, A, Greenberg, SM, Bennett, DA, De Jager, PL, Rosand, J, Biffi, A, ADNI. TOMM40 in CAA-related ICH: Comparative Genetic Analysis with Alzheimer’s Disease. Translational Stroke Research. 2012; 3(S1):102-112. [PDF]

research graphLim, ASP, Chang, AM, Shulman, JM, Raj, T, Chibnik, LB, Myers, AJ, Buchman, AS, Bennett, DA, Cain, SW, Czeisler, CA, Duffy, JF, Saper, CB, De Jager, PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Annals of Neurology. 2012; 72:324-334. PMCID: PMC3464954. [PDF]

Hek, K, Demirkan, A, Lahti, J, ... Shulman, JM, ... Newman, AB, Tiemeier, H, Murabito, J. A Genome-Wide Association Study of Depressive Symptoms. Biological Psychiatry. In press. [PDF]

Buchman, AS, Nag, S, Shulman, JM, Lim, ASP, VanderHorst, VGJM, Leurgans, SE, Schneider, JA, Bennett, DA. Locus Coeruleus Neuron Density and Parkinsonism in Older Adults without Parkinson’s Disease. Movement Disorders. 2012; 27:1625-1631. [PDF]research image

Buchman, AS, Shulman, JM, Leurgans, SE, Schneider, JA, and Bennett, DA. Reply. Annals Neurol 2012; 72:298.

Shulman, JM and Schneider, JA. Molecular mechanisms of cortical degeneration in Parkinson disease. Neurology. 2012; 79: 1750-1751. [PDF]

2011

Shulman, JM, Chipendo, PC, Chibnik, L.B., Keenan, B.T., Aubin, C, Tran, D, Kramer, P, Schneider, J.A., Bennett, DA, Feany, MB, De Jager, PL. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. American Journal of Human Genetics. 2011; 88:232-238. [PDF]

Chibnik, LB, Shulman, JM, Leurgans, S, Shneider, JA,  Wilson, RS, Tran, D, Aubin, C, Huentelman, MJ, Reiman, EM, Evans, DA, Bennett, DA, De Jager, PL. The Alzheimer’s susceptibility locus CR1 is associated with increased amyloid plaque burden and age-related cognitive decline. Annals of Neurology. 2011; 69:560-569. [PDF]

Treusch, S, Hamamichi, S, Goodman, JL, Matlack, KES, Chung, CY, Baru, V, Shulman, JM, Parrado, A, Bevis, BJ, Valastyan, JS, Han, H, Lindhagen-Persson, M, Reiman, EM, Evans, DA, Bennett, DA, Olofsson, A, De Jager, PL, Tanzi, RE, Caldwell, KA, Caldwell, research imageGA, Lindquist, S. A yeast model establishes a functional connection between Aβ Toxicity and endocytic trafficking and Alzheimer’s Disease risk factors. Science. 2011; 334:1241-1245. [PDF]

Shulman, JM, De Jager, PL, Feany, MB. Parkinson’s disease: Genetics and Pathogenesis. Annual Reviews of Pathology: Mechanisms of Disease 2011; 6:193-222. [PDF]

2010

Shulman, JM, Chibnik, LB, Aubin, C, Schneider, J, De Jager, P, and Bennett, D. Intermediate phenotypes identify divergent pathways to Alzheimer’s disease. PLoS ONE 2010; 5(6): e11244. [PDF]

Xia, Z,  Chibnik, LB, Glanz, BI, Liguori, M., Shulman, JM, Tran, D, Khoury, SJ, Chitnis, T, Holyoak, T, Weiner, HL, Guttmann, CRG, De Jager, PL. An Alzheimer's disease Risk Allele in PCK1 Influences Brain Atrophy in Multiple Sclerosis. PLoS ONE 2010; 5(11): e14169. [PDF]

Corneveaux, JJ, Myers, AJ, Allen, AN, Pruzin, JJ, Ramirez, M, Engel, A, Nalls, MA, Chen, K, Lee, W, Chewning, K, Villa, SE, Meechoovet, HB, Gerber, JD, Frost, D, Benson, HL,  O'Reilly, S, Chibnik, LB, Shulman, JM, Singleton, A, Craig, DW, Van Keuren-Jensen, KR, Dunckley, T,  Bennett, DA, De Jager, PL, Heward, C, Hardy, J, Reiman, EM, Huentelman, MJ. Association of CR1, CLU, and PICALM with Alzheimer's disease in a cohort of clinically and characterized and neuropathologically verified individuals. Human Molecular Genetics 2010; 19:3295-3301. [PDF]

Shulman, JM. Incidence and Risk for Dementia in Parkinson Disease. Journal Watch: Neurology 2010; 12(4):28.

research image2009

Shulman, JM and De Jager, P.L. Evidence for a common pathway linking neurodegenerative diseases. Nature Genetics 2009; 41:1261-1262. [PDF]

2008

Alcalay, RN, Shulman, JM, and Plotkin, SR. Ramsay Hunt syndrome in a patient with metastatic lung cancer to brain. Journal of Neurooncology 2008; 86:55-56. [PDF]

2007

Steinhilb, ML, Dias-Santagata, D, Mulkearns, EE, Shulman, JM, Biernat, J, Mandelkow, EM and Feany, MB. S/P and T/P phosphorylation is critical for tau neurotoxicity in DrosophilaJournal of Neuroscience  Research 2007;85:1271-1278. [PDF]

2006

Khurana, V, Lu, Y, Steinhilb, M, Oldham, S, Shulman, JM, and Feany MB. TOR-mediated cell cycle activation causes neurodegeneration in a Drosophila tauopathy model.  Current Biology 2006; 16:1-12. [PDF]

2005

Shulman, JM. Wing of Fly, Tail of Rodent, Scale of Fish, and Pinch of Yeast: Cooking Up the Ultimate Animal Model in Movement Disorders. Moving Along 2005;7(1):1.

2004

Shulman, JM.  Surgical Lessons from Shakespeare. Current Surgery 2004; 61:96-97.

2003

Doerflinger, H, Benton, R, Shulman, JM, and St Johnston, D. The role of PAR-1 in regulating the polarised microtubule cytoskeleton in the Drosophila follicular epithelium. Development 2003; 130:3965-3975. [PDF]

Shulman, JM and Feany, MB. Genetic modifiers of tauopathy in Drosophila. Genetics 2003; 165:1233-1242. [PDF]

fruit fly eye

Shulman, JM, Shulman, LM, Weiner, WJ, and Feany, MB.  From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease. Current Opinion in Neurology 2003; 16:443-449. [PDF]

2002

Tree, DRP, Shulman, JM, Gubb, D, and Axelrod, JD.  Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.  Cell 2002;109:371-381. [PDF]

2001

Huynh, J-R, Shulman, JM, Benton, R, and St Johnston, D.  PAR-1 is required for the maintenance of oocyte fate in Drosophila. Development 2001; 128:1201-1209. [PDF]

Wittman, CW, Wszolek, MF, Shulman, JM, Salvaterra, PM, Lewis, J, Hutton, M., Feany, MB. Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles. Science 2001; 293:711-714. [PDF]

2000

research image

Shulman, JM, Benton, R., and St Johnston, D. A Drosophila homolog of C. elegans PAR-1 organizes the oocyte cytoskeleton and directs oskar mRNA localization to the posterior pole. Cell 2000; 101:377-388. [PDF]

1999

Shulman, JM and St Johnston, D. Pattern formation in single cells. Trends in Cell Biology 1999; 9:M60-M64. [PDF]

1998

Axelrod, JD, Miller, JR, Shulman, JM, Moon, RT, and Perrimon, N.  Differential recruitment of Dishevelled provides signaling specificity in the Planar Cell Polarity and Wingless signaling pathways.  Genes and Development 1998; 12:2610-2622. [PDF]

Shulman, JM, Perrimon, N., and Axelrod, JD. Frizzled Signaling and the Developmental Control of Cell Polarity.  Trends in Genetics 1998; 14:452-458.

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